Multi-gene test for Hereditary Cancer
(Including BRCA1 & BRCA2 genes)
HerediGENE® is a diagnostic multi-gene test for hereditary cancer, which analyses 52 genes, including BRCA1 and BRCA2, which are involved in the increased risk of breast, ovarian, prostate, colorectal and other hereditary cancers.
| Cancer Types |
|---|
| Breast, Colorectal, Prostate, Pancreatic, Ovarian, Gastric, Melanoma, Thyroid, Kidney, Endometrial |
| Cancer Syndromes |
|---|
| Hereditary Breast and Ovarian Cancer Syndrome, Lynch Syndrome, Cowden Syndrome, Li-Fraumeni Syndrome, Peutz-Jeghers Syndrome, Familial Adenomatous Polyposis, Von-Hippel Lindau Syndrome, Multiple Endocrine Neoplasia, Other. |
A person with an inherited pathogenic mutation is at increased risk for developing certain type of cancer. The gene profile therefore offers important information for the treatment of patients and the management of themselves and their families.
The HerediGENE® analyzes 52 genes, which are involved in the cancer susceptibility, 21 of which are related to Homologous Recombination (HR).
| Colon | Breast | Pancreas | Ovarian | Gastric | Melanoma | Endometrial | Endocrine | Prostate | HRD | Associated Syndrome |
|---|---|---|---|---|---|---|---|---|---|---|
| APC | APC | APC | APC | Familial Adenomatous Polyposis | ||||||
| ATM | ATM | ATM | ATM | ATM | Ataxia Telangilectasia (recessive) | |||||
| AXIN2 | Polyposis/Oligodontia | |||||||||
| BARD1 | BARD1 | BARD1 | ||||||||
| BMPR1A | BMPR1A | Juvenile Polyposis Sydrome | ||||||||
| BRCA1 | BRCA1 | BRCA1 | BRCA1 | BRCA1 | BRCA1 | Hereditary Breast and Ovarian Cancer | ||||
| BRCA2 | BRCA2 | BRCA2 | BRCA2 | BRCA2 | BRCA2 | Hereditary Breast and Ovarian Cancer, Fanconi anaemia FA-D1 (recessive) | ||||
| BRIP1 | BRIP1 | BRIP1 | Fanconi anaemia FA-J (recessive) | |||||||
| CDH1 | CDH1 | Hereditary diffuse gastric cancer | ||||||||
| CDK4 | ||||||||||
| CDKN2A | CDKN2A | Familial Atypical Mole-Malignant Melanoma Syndrome (FAMMM) | ||||||||
| CHEK2 | CHEK2 | CHEK2 | CHEK2 | |||||||
| EPCAM | EPCAM | EPCAM | EPCAM | Lynch Syndrome | ||||||
| FANCA | Fanconi anaemia FA-A (recessive) | |||||||||
| FANCL | Fanconi anaemia FA-L (recessive) | |||||||||
| FANCM | Fanconi anaemia FA-M (recessive) | |||||||||
| HOXB13 | ||||||||||
| MEN1 | Multiple endocrine neoplasia Type1 | |||||||||
| MLH1 | MLH1 | MLH1 | MLH1 | MLH1 | Lynch Syndrome / Constitutional mismatch repair deficiency (CMMRD) syndrome (recessive) | |||||
| MRE11 | Ataxia-telanglectasia-like disorder (recessive) | |||||||||
| MSH2 | MSH2 | MSH2 | MSH2 | MSH2 | Lynch Syndrome | |||||
| MSH3 | Adenomatous Polyposis (recessive) | |||||||||
| MSH6 | MSH6 | MSH6 | MSH6 | Lynch Syndrome | ||||||
| MUTYH | MUTYH-associated polyposis | |||||||||
| NBN | NBN | Nijmegen breakage syndrome (recessive) | ||||||||
| NF1 | NF1 | NF1 | NF1 | Neurofibromatosis Type1 | ||||||
| NTHL1 | Adenomatous Polyposis (recessive | |||||||||
| PALB2 | PALB2 | PALB2 | PALB2 | PALB2 | Fanconi anaemia FA-N (recessive) | |||||
| PMS2 | PMS2 | PMS2 | Lynch Syndrome | |||||||
| POLE | Adenomatous Polyposis | |||||||||
| POLD1 | Adenomatous Polyposis | |||||||||
| PPP2R2A | ||||||||||
| PTEN | PTEN | PTEN | PTEN | PTEN | Cowden | |||||
| RAD50 | RAD50 | Nijmegen breakage syndrome like disorder (recessive) | ||||||||
| RAD51B | ||||||||||
| RAD51C | RAD51C | RAD51C | Fanconi anaemia FA-O (recessive) | |||||||
| RAD51D | RAD51D | RAD51D | Fanconi anaemia (recessive) | |||||||
| RET | Multiple endocrine neoplasia Type2 | |||||||||
| SMAD4 | SMAD4 | Juvenile Polyposis / Hereditary hemorhagic telanglectasia (HHT) | ||||||||
| SMARCA4 | AD small cell carcinoma of the ovary hypercalcemic type (SCCOTH), AD rhabdoid tumor predisposed lion syndrome type 2 (RTPS2) | |||||||||
| STK11 | STK11 | STK11 | STK11 | STK11 | STK11 | Peutz-Jeghers Sydrome | ||||
| TP53 | TP53 | TP53 | TP53 | TP53 | Li-Fraumeni Sydrome | |||||
| VHL | von Hippel-Lindau Sydrome |
What types of cancer does it cover?
The examination mainly covers the occurrence of breast and ovarian, prostate, colorectal, pancreatic, kidney, gastric, thyroid and melanoma cancers.
Are BRCA1/2 genes included?
Yes, the BRCA1/2 genes are included in addition to 41 more genes shown in the panel.
If a pathogenic mutation is found, should all family members be tested?
The results obtained by the test are useful for the entire family, as it is enough for a person to inherit a mutation from one parent, to be at increased risk of developing cancer. A child whose parent is a mutant carrier has a 50% chance of inheriting the mutation. More distant relatives are also at risk of carrying the mutation. Individuals who may be carriers of inherited gene mutation can be identified by referral for genetic testing. Note that hereditary cancer susceptibility syndromes can be associated with many different types of cancer. Therefore, a mutation detected in the sample for breast or ovarian cancer may be associated with an increased risk of pancreatic or prostate cancer.
In how many days will the results be available?
Results will be available in 20 business days.
What type of sample is required for the test?
Whole peripheral blood in EDTA vials (2 vials) or saliva in a special kit supplied by our company.
Is blood sampling performed at the Genekor facility?
No, the company does not perform blood samplings, so you should contact us at 210-6032138 and we will guide you.
Is the test covered by any public/private insurance?
For cost coverage, please contact the secretariat here.
Following the launch of e-prescribing for BRCA 1,2 gene mutation testing for hereditary breast and ovarian cancer, please find below the Electronic Prescription Template with the relevant detailed e-prescribing instructions for BRCA 1,2 genes for the 4 different cases.
Case 1: Women diagnosed with Ca breast before the age of 45
Case 2: Women diagnosed with Breast Ca at age greater than or equal to 45 years with Family History
Case 3: Women diagnosed with malignant epithelial neoplasm of the ovary
Case 4: Women with a known BRCA1/2 mutation in the family
How do I make the payment for the test?
Payment can be made by bank transfer or debit/credit card
How I send the sample and receive the results?
Regarding the receipt of the sample, please contact the secretariat. The results are shared with your doctor and with you via email.
Our Customer Service Team is committed to answer your questions with regards to the services offered by Genekor. If you would like to order any of the tests that Genekor performs please contact us directly.
*To complete the test, you are required to complete and send the Consent form that you will find on the link below.
*For more information on scientific content please contact: scientific.support@genekor.com
*Download the promotional brochure here.
*Order in the United Arab Emirates here.